Glaucoma is a term encompassing a variety of diseases that culminate in the death of retinal ganglion cells (RGC). Although a variety of factors can initiate the disease onset, increased intraocular pressure (IOP) is one of the major risk factors. In our previous study we found that semaphorins were causally involved in RGC death following axotomy. Since a common feature of all Glaucoma is a term encompassing a variety of diseases that culminate in the death of retinal ganglion cells (RGC). study we found that semaphorins were causally involved in RGC death following axotomy. Since a common feature of all