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目的探讨未足月胎膜早破(PPROM)不同时间应用抗生素治疗对分娩结局的影响。方法选取2013年8月至2016年8月茂名市电白区妇幼保健院(PPROM)患者102例为研究对象,均口服头孢呋辛酯片,按照用药时间(胎膜早破至使用抗生素)分为3组:<12 h为A组34例,12~24 h为B组,>24 h为C组,每组34例。比较3组治疗方式对分娩结局的影响。结果 A组患者宫内感染、产褥感染与产后出血的发生率最低,其次为B组,但是A组与B组入院至分娩时间长。C组患者宫内感染、产后出血、产褥感染的发生率均高于A组及B组,而入院至分娩时间>48 h发生率低于A组与B组,差异均有统计学意义(均P<0.05)。A组与B组新生儿结局正常者均高于C组,轻度窒息发生率低于C组,差异均有统计学意义(均P<0.05)。结论对(PPROM)孕妇尽早应用抗生素,可以降低感染风险,有效改善母婴结局。
Objective To investigate the effect of antibiotic treatment on delivery outcome in PPROM at different times. Methods From August 2013 to August 2016, 102 patients with PPROM in Dianbai District of Maoming City were enrolled in this study. All patients were given oral cefuroxime axetil tablets according to the time of medication (premature rupture of membranes to antibiotics) Three groups: <12 h in group A 34 cases, 12-24 h in group B,> 24 h in group C, 34 cases in each group. The effects of three treatment methods on delivery outcome were compared. Results The incidence of intrauterine infection, puerperal infection and postpartum hemorrhage in group A was the lowest, followed by group B, but the time between admission and delivery in group A and group B was longer. The incidence of intrauterine infection, postpartum hemorrhage and puerperal infection in group C were higher than those in group A and group B, while the incidence of admission to delivery 48 hours was lower than that in group A and group B (P < All P <0.05). The neonatal outcome was normal in group A and group B than in group C, and the incidence of mild asphyxia was lower than that in group C (all P <0.05). Conclusions The early application of antibiotics to pregnant women with PPROM can reduce the risk of infection and effectively improve the maternal and infant outcomes.