论文部分内容阅读
目的 通过对乳腺癌创面游离癌细胞的定性研究 ,探讨术中温热低渗浸泡化疗在预防其复发的效果。方法 将 94例乳腺癌患者分成实验组 (n =48)和对照组 (n =46)。取两组创面冲洗液送检找癌细胞。然后实验组手术创面用 41℃～ 42℃生理盐水 3 0 0 0ml +氟脲嘧啶 1.0g浸泡化疗 ,每次 5min ,分 3～ 4次。对照组手术创面用等量生理盐水浸泡。两组再取浸泡液送检找癌细胞。并对两组癌细胞检出率和乳癌术后局部复发率进行对照研究。结果 冲洗液癌细胞检出率实验组为 2 9.2 % ,对照组为 2 6.1% (P >0 .0 5 ) ;浸泡液癌细胞检出率实验组为 8.3 % ,对照组为19 .6% (P <0 .0 5 )。术后局部复发率实验组为 6.3 % ,对照组为 15 .2 % (P <0 .0 5 )。结论 乳腺癌术后创面有脱落癌细胞。术中温热浸泡化疗可以杀灭游离癌细胞 ,降低局部复发率。
Objective To study the effect of intraoperative hypothermia and infiltration chemotherapy in preventing recurrence of breast cancer by qualitative research on the free cancerous cells in breast cancer. Methods 94 patients with breast cancer were divided into experimental group (n = 48) and control group (n = 46). Take two sets of wound washing liquid sent to find cancer cells. Then the experimental group wounds were treated with 4100ml ~ 42ml normal saline 3000ml + fluorouracil 1.0g for 5 ~ 5min every 3 ~ 4 times. Control group wounds were treated with the same amount of saline soaked. Two groups then take soaking liquid sent to find cancer cells. The detection rate of the two groups of cancer cells and the local recurrence rate after breast cancer were compared. Results The detection rate of cancer cells in washing fluid was 22.2% in experimental group and 26.1% in control group (P> 0.05). The detection rate of cancer cells in soaking fluid was 8.3% in experimental group and 19.6% in control group (P <0. 05). The local recurrence rate was 6.3% in the experimental group and 15.2% in the control group (P <0.05). Conclusion Breast cancer wounds have shed cancer cells. Intraoperative warm soaking chemotherapy can kill free cancer cells and reduce the local recurrence rate.