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目的:观察奥曲肽和垂体后叶素治疗肝硬化食管曲张静脉破裂出血的疗效及对门脉血流动力学的影响。方法:75例病人经胃镜证实有食管中、下段静脉曲张破裂出血。男57例,女18例。奥曲肽组38例;垂体后叶素组37例。治疗组用奥曲肽0.1 mg+生理盐水20ml静推,后用0.05mg/h的速度静脉滴注维持24小时。对照组用垂体后叶素5u+生理盐水20 ml静推,继以0.4 u/min静滴维持24小时。静推药物后插胃管每2小时抽吸胃液一次,不再有血液抽出为止血时间。用彩色多普勒超声仪于用药前及用药24小时后分别探测门脉主干内径、最大血流速度及血流量。结果:奥曲肽总有效率86.84%,垂体后叶素组为62.16%,有显著差异(P<0.025)。结论:奥曲肽组门脉内径、血流速度及血流量降低更为明显。
Objective: To observe the curative effect of octreotide and vasopressin on hepatic cirrhosis with esophageal variceal bleeding and portal vein hemodynamics. Methods: 75 cases of patients confirmed by endoscopy esophageal, lower varicose vein hemorrhage. 57 males and 18 females. Octreotide group 38 cases; pituitrin group 37 cases. Treatment group with octreotide 0.1 mg + saline 20ml static push, after the 0.05mg / h speed intravenous infusion for 24 hours. The control group with pituitrin 5u + saline 20 ml static push, followed by intravenous infusion of 0.4 u / min for 24 hours. After the drug is inserted, the gastric juice is aspirated once every 2 hours, no more blood is taken out to stop bleeding. Color Doppler ultrasound before treatment and 24 hours after drug use were detected portal vein diameter, maximum blood flow velocity and blood flow. Results: The total effective rate of octreotide was 86.84% and that of pituitary hormone was 62.16% (P <0.025). Conclusion: The decrease of portal vein diameter, blood flow velocity and blood flow in octreotide group is more obvious.