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目的 探讨几种容易发生过敏反应的药物在新生儿时期应用时是否可以不作过敏试验。方法 于 1978年 6月至 2 0 0 1年 6月对我院新生儿病房住院的 5 84 3例新生儿 ,应用青霉素、细胞色素C、普鲁卡因、破伤风抗毒素几种药物时不作过敏试验直接用药 ,用药后严密观察病情变化。结果 经 2 3年对 5 84 3例新生儿不作过敏试验 ,直接应用上述几种药物 ,通过临床严密观察 ,没有 1例发生过敏反应。结论 新生儿是一特殊群体 ,此时期机体免疫功能暂时缺陷 ,免疫生理及免疫病理与成人有一定差别 ,新生儿期不易发生典型的速发型变态反应。经 2 3年临床用药观察未发现一例新生儿出现过敏反应。
Objective To investigate whether several drugs susceptible to anaphylaxis can be used in neonatal period without allergy test. Methods From June 1978 to June 2001, 5 843 newborns hospitalized in our hospital neonatal ward were not allergic to several drugs such as penicillin, cytochrome C, procaine and tetanus antitoxin Test direct medication, medication closely observe the changes in condition. Results No allergy test was carried out in 5 843 newborns over the past 23 years. The above drugs were directly used. No allergic reaction occurred in 1 patient. Conclusion Neonatal is a special group. The immune function of the newborn is temporarily deficient. The immunopathology and immunopathology are different from those of adults. The onset of typical immediate-onset allergic reactions is not likely to occur during the neonatal period. After 23 years of clinical observation did not find a case of neonatal allergic reactions.