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用酶联免疫吸附试验（ＥＬＩＳＡ）检测１２３例乙型肝炎表面抗原（ＨＢｓＡｇ）阳性的各期血吸虫病患者及５０例ＨＢｓＡｇ阳性的非血吸虫病对照人群血清丁型肝炎病毒（ＨＤＶ）标志物，用斑点杂交检测晚期血吸虫病（晚血，ＡＳ）患者ＨＢＶ－ＤＮＡ。结果表明，ＨＢｓＡｇ阳性的晚血患者ＨＤＶ标志物（ＨＤＶ－Ｍ）检出率１４．５％，显著高于急性血吸虫病（急血）、慢性血吸虫病（慢血）患者（２．５％）及对照人群（２．０％）（Ｐ＜０．０５）。随访观察发现，ＨＢＶ／ＨＤＶ双重感染的晚血患者病死率４０％，显著高于单纯ＨＢＶ感染的晚血患者（８．５％，Ｐ＜０．０５），提示晚血患者是ＨＤＶ感染的易感人群，ＨＤＶ感染是ＨＢｓＡｇ阳性晚血患者病情加重或恶化的一个重要原因，ＨＢＶ／ＨＤＶ双重感染与晚血患者死亡密切相关。
Enzyme-linked immunosorbent assay (ELISA) was used to detect 123 hepatitis B surface antigen (HBsAg) -positive stages of schistosomiasis patients and 50 HBsAg-positive non-schistosomiasis control subjects serum hepatitis B virus (HDV) markers, with Detection of HBV-DNA in patients with advanced schistosomiasis (late blood, AS) by dot blot hybridization. The results showed that the HDV-M detection rate was 14.5% in HBsAg-positive patients with late-onset blood, significantly higher than those in acute schistosomiasis (acute blood) and chronic schistosomiasis (2.5%) And control subjects (2.0%) (P <0.05). Follow-up observation found that the mortality of patients with HBV / HDV double infection was 40%, significantly higher than that of patients with pure HBV infection (8.5%, P <0.05), suggesting that patients with late blood are HDV-infected Influenza, HDV infection is HBsAg-positive patients with late blood aggravating or worsening an important reason, double infection of HBV / HDV and late death of patients with blood are closely related.