目的核查并分析梅毒报告病例的实验室检查结果,为客观分析广州市梅毒疫情并制定下一步的梅毒防治措施提供依据。方法设制统一的核查表,从大疫情网下载广州市2012年报告的梅毒病例,根据历年梅毒流行特征,按隐性∶一期∶二期∶其他=5∶2∶2∶1的比例抽样,通过现场调查进行核查,资料统一录入数据库,用SPSS19.0软件分析。结果共核查2 402例梅毒,报告率为31.47%,其中RPR和TPPA双阳性者占58.49%,TPPA单阳性者占8.12%,RPR单阳性者占16.28%,仅TP-ELISA等筛查单阳性者占4.58%,4.50%病例为临床报告。在RPR和TPPA双阳性的报告病例中,未行RPR定量检测的占12.95%;已检测的RPR滴度中,二期梅毒RPR≥1:16者占61.07%,而隐性梅毒和胎传梅毒RPR≤1∶8者分别占82.21%和78.79%。结论广州市网络直报梅毒存在不合理诊断和报告,要加强梅毒网络疫情报告质量管理,加强临床医生对梅毒诊断,尤其是实验室检查项目规范利用的培训,提高梅毒报告质量。 Objective To verify and analyze the laboratory test results of syphilis reported cases and provide the basis for objective analysis of the epidemic situation of syphilis in Guangzhou and to make the next step of syphilis prevention and control measures. Methods To establish a unified checklist to download the 2012 cases of syphilis reported by Guangzhou from the epidemic outbreak, according to the epidemiological characteristics of syphilis over the years, according to the recessive: one: two: the other = 5: 2: 2: 1 ratio sampling , Through the field survey to verify the data entered into the database unified, with SPSS19.0 software analysis. Results A total of 2 402 syphilis cases were checked, with a reported rate of 31.47%. Among them, 58.49% were positive for RPR and TPPA, 8.12% were positive for TPPA, 16.28% were positive for RPR alone, only positive for screening test such as TP-ELISA Accounting for 4.58%, 4.50% of cases were clinical reports. RPR and TPPA double positive in the reported cases, not RPR quantitative detection accounted for 12.95%; detected RPR titers, two syphilis RPR ≥ 1: 16 accounted for 61.07%, while the latent syphilis and fetal syphilis RPR≤1: 8 accounted for 82.21% and 78.79% respectively. Conclusion There is an unreasonable diagnosis and report of syphilis in network reporting in Guangzhou City. Quality control of syphilis network epidemic reporting should be strengthened to enhance clinicians’ training on syphilis diagnosis, especially the standardized use of laboratory inspection items, and to improve the quality of syphilis reporting.