【摘 要】
：
Five novel biscembranoids, ximaolides H-L (1-5), along with four known related compounds (6-9) were isolated from the Hainan soft coral Sarcophyton tortuosum. T
【机 构】
：
State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Scienc
论文部分内容阅读
Five novel biscembranoids, ximaolides H-L (1-5), along with four known related compounds (6-9) were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of the new compounds were determined by extensive spectroscopic analysis, quantum chemical calculations, and/or by comparing their CD spectra with those of the known compounds. Compounds 1 and 2 are the first examples of biscembranoids bearing a 1,35-bridged lactone moiety, 4 is the first biscembranoid comprising an uncommon oxetane ring, and 5 represents the first 36-peroxyl biscembranoid. Ximaolides I (2), K (4) and F (9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-α protein release in RAW264.7 macrophages.
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