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目的 :研究植物黄酮类治疗糖尿病药理机制。方法 :选取96例糖尿病患者作为研究对象,根据是否采取植物黄酮类治疗进行分组;对照组占46.88%(45/96),积极采取降糖治疗;观察组占53.12%(51/96),在降糖治疗的基础上,采取植物黄酮类治疗,肌注银杏叶提取物注射液,每次5m L;以空腹血糖(FPG)、糖化血红蛋白(GHb A1c)、餐后2h血糖(2h PG)为疗效观察指标,并对比治疗前后的胰岛素抵抗指数(HOMA-IR)、胰岛β细胞指数(HOMA-β)。结果 :两组FPG、GHb A1c、2h PG水平对比,治疗前,差异不显著(P>0.05);治疗后,观察组低于对照组,差异显著(P<0.05);治疗后,观察组HOMA-IR、HOMA-β较治疗前的改善程度大于对照组,差异显著(P<0.05)。结论:植物黄酮类治疗糖尿病具有确切的降糖作用,药理机制与提高胰岛β细胞功能、抑制胰岛素抵抗有关。
Objective: To study the pharmacological mechanism of plant flavonoids in the treatment of diabetes. Methods: Ninety-six patients with diabetes mellitus were enrolled in this study. The patients in the control group were divided into groups according to their flavonoids treatment. The control group accounted for 46.88% (45/96), and the patients in the observation group took 53.12% (51/96) On the basis of hypoglycemic treatment, taking plant flavonoids, intramuscular Ginkgo biloba extract injection, each 5m L; with fasting blood glucose (FPG), glycosylated hemoglobin (GHb A1c), 2h postprandial blood glucose Efficacy indicators, and compared before and after treatment of insulin resistance index (HOMA-IR), pancreatic β-cell index (HOMA-β). Results: The levels of FPG, GHb A1c and 2h PG in the two groups were not significantly different before treatment (P> 0.05). After treatment, the observation group was lower than the control group (P <0.05); after treatment, the HOMA -IR, HOMA-β improved more than before treatment, the difference was significant (P <0.05). Conclusion: The plant flavonoids have the exact hypoglycemic effect on diabetes mellitus, and the pharmacological mechanism is related to improving the function of pancreatic β cells and inhibiting the insulin resistance.