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人们对人群中的异染色质变异体的生物学和临床意义的研究有着浓厚的兴趣。最近报告恶性肿瘤患者的异染色质多态性的出现率有差异,包括神经系肿瘤、睾丸肿瘤、软组织肉瘤、肾细胞癌,卵巢、膀胱及乳腺癌。最近还报导了对结肠癌患者染色质变异体研究的不同结果。本文分析了结肠腺癌(CA)和结肠癌(CC)患者C带的多态性,以此确定异染色质变异体与其病理发生的关系。
There is a strong interest in the study of the biological and clinical significance of heterochromatin variants in the population. The incidence of heterochromatin polymorphisms has recently been reported in patients with malignant tumors, including neurological tumors, testicular tumors, soft tissue sarcomas, renal cell carcinoma, ovary, bladder, and breast cancer. Recently, different results for the study of chromatin variants in patients with colon cancer have also been reported. This paper analyzes the polymorphisms of C-band in patients with colon adenocarcinoma (CA) and colon cancer (CC) to determine the relationship between heterochromatin variants and their pathological occurrence.