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本试验综合高氧肿瘤增敏治疗与低氧正常组织防护的效应 ,先后吸入高氧 (HO)低氧 (LO)浓度的气体 ,在对肿瘤增敏的同时尽量减少对正常组织的损伤程度 ,并加用适当的药物予以修饰 ,通过动物实验验证这一方法对实验肿瘤的放疗效果。结果表明 :HO +LO对肿瘤组织有明显增敏作用 ,其程度与单纯吸HO相似。所用药物与HO或HO +LO配伍用时 ,对肿瘤的效价比单纯HO或LO略高。
In this study, the effect of hyperoxic tumor hypersensitivity therapy and hypoxia-normal tissue protection was studied. Inhalation of gas with high concentration of oxygen (HO) and low concentration of oxygen (LO) led to sensitization to the tumor and minimized the damage to normal tissues. And add appropriate drugs to be modified by animal experiments to verify the method of radiation on the experimental tumor radiotherapy. The results showed that HO + LO significantly enhanced the sensitivity of tumor tissue to a similar extent as that of HO alone. The drug used in combination with HO or HO + LO, the potency of the tumor than the simple HO or LO slightly higher.