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目的研究槐杞黄颗粒治疗支气管哮喘非急性发作期患儿的临床疗效及对免疫功能的影响。方法选取2015年4月至2016年11月我院收治的72例非急性发作期支气管哮喘患儿作为研究对象,采用随机数字表法分为治疗组和对照组,各36例。对照组予以常规西医疗法,治疗组在对照组治疗方法的基础上加槐杞黄颗粒,治疗2月后比较2组用药前、后哮喘控制情况,临床疗效,并观察治疗组免疫功能的变化情况。结果治疗组总有效率为94.44%,显著高于对照组的58.33%,差异有统计学意义(P<0.05)。治疗后,2组日间症状发作次数积分、夜间症状发作次数积分、夜间症状以及觉醒程度积分比较差异均无统计学意义(P>0.05),而治疗组日间症状发作程度积分显著低于对照组,差异有统计学意义(P<0.05)。与治疗前比较,治疗后治疗组Ig A以及Ig M变化不明显(P>0.05),Ig G显著增加(P<0.05),同时总T淋巴细胞及T淋巴细胞亚群显著增加,总B淋巴细胞显著减少,差异均有统计学意义(P<0.05)。结论槐杞黄颗粒治疗支气管哮喘非急性发作期患儿临床疗效确切,且可显著改善患儿日间症状发作程度,提高机体免疫功能。
Objective To study the clinical efficacy of Huaiqi Huang granule in treating children with bronchial asthma during non-acute attack and its effect on immune function. Methods From April 2015 to November 2016, 72 children with bronchial asthma without acute exacerbation were enrolled in this study. The patients were randomly divided into treatment group and control group, with 36 cases in each group. The control group was treated with conventional western medicine. The treatment group was given Huai Qi Huang granules on the basis of the control group, and the two groups were compared after 2 months of treatment with asthma control, clinical efficacy and the changes of immune function in the treatment group . Results The total effective rate of the treatment group was 94.44%, which was significantly higher than that of the control group (58.33%), the difference was statistically significant (P <0.05). After treatment, there were no significant differences between the two groups in the number of symptom onset episodes, the number of nighttime symptom episodes, nocturnal symptoms, and awakening degree points (P> 0.05), while the scores of the daytime symptom episodes in the treatment group were significantly lower than those in the control Group, the difference was statistically significant (P <0.05). Compared with that before treatment, IgA and IgM in the treatment group did not change significantly (P> 0.05), Ig G increased significantly (P <0.05), meanwhile the total T lymphocytes and T lymphocyte subsets increased significantly, while the total B lymph Cells were significantly reduced, the difference was statistically significant (P <0.05). Conclusion Huaiqi Huang granules in the treatment of bronchial asthma in patients with non-acute attack of clinical efficacy is exact, and can significantly improve the degree of onset of daytime symptoms in children and improve immune function.