心得安已被广泛用于甲亢的术前准备和预防甲状腺危象。但单独服用心得安对甲亢症状的改善有时井不满意,常规剂量的心得安并非都能防止危象发生,失败原因很可能是血浆含药量不足。作者研究心得安的药物代谢动力学,发现甲亢病人服药后血浆浓度的差异很大。单次口服心得安80毫克后,对照组和甲亢组一样,血浆最高浓度差异均很大,对照组为59～226毫微克/毫升;甲亢组为54～211毫微克/毫升。最高浓度与体重、体表面积都不相 Experience has been widely used in hyperthyroidism preoperative preparation and prevention of thyroid crisis. However, taking propranolol alone improves the symptoms of hyperthyroidism sometimes unsatisfied with the well-being of conventional doses, not all can prevent the crisis, the reason for the failure may be insufficient plasma content. The authors study the safety of the drug pharmacokinetics, found that patients with hyperthyroidism plasma concentration after taking a great difference. A single oral propranolol 80 mg, the control group and hyperthyroidism group, the highest plasma concentrations were large differences in the control group was 59 to 226 ng / ml; hyperthyroidism group was 54 to 211 ng / ml. The highest concentration and weight, body surface area is not the same