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目的探讨血管内皮生长因子-C(VEGF-C)和淋巴管内皮透明质酸受体-1(LYVE-1)在卵巢上皮性肿瘤中的表达及其与临床病理因素之间的关系。方法免疫组织化学SP法检测61例卵巢肿瘤患者手术标本中VEGF-C及LYVE-1的表达,分析其与临床病理因素的关系。结果①VEGF-C及LYVE-1在卵巢上皮性癌中的表达均明显高于卵巢交界性肿瘤和卵巢良性肿瘤(P<0.01);②VEGF-C及LYVE-1的表达与卵巢上皮性癌患者年龄、组织学分级、组织学类型无关(P>0.05),但与临床分期、淋巴结转移相关(P<0.05)。结论VEGF-C和LYVE-1在卵巢上皮性肿瘤淋巴转移过程中发挥了重要作用。
Objective To investigate the expression of vascular endothelial growth factor-C (VEGF-C) and lymphatic endothelial hyaluronic acid receptor-1 (LYVE-1) in ovarian epithelial neoplasms and its relationship with clinicopathological factors. Methods Immunohistochemical SP method was used to detect the expression of VEGF-C and LYVE-1 in surgical specimens of 61 patients with ovarian neoplasm. The relationship between VEGF-C and LYVE-1 was analyzed with clinicopathological factors. Results ① The expressions of VEGF-C and LYVE-1 in ovarian epithelial carcinoma were significantly higher than those in borderline ovarian and benign ovarian tumors (P <0.01). ② The expressions of VEGF-C and LYVE-1 were significantly correlated with the age of ovarian epithelial carcinoma , Histological grade and histological type (P> 0.05), but not related to clinical stage and lymph node metastasis (P <0.05). Conclusion VEGF-C and LYVE-1 play an important role in the lymphatic metastasis of epithelial ovarian tumors.