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家兔早期妊娠胚胎130个,分为4组,宫腔内注射优降宁(优)6mg 和/或利血平(利)0.19mg,妊娠终止率:对照组7.7%,优组12.0%,利组19.3%,优利序贯给药组89.6%,呈显著协同作用(P<0.001)。如把优、利总量作静脉注射,胚胎死亡率仅23.2%。预先静脉注射酚苄明,可使优、利宫腔给药的抗孕效果降低至46.1%。说明优、利抗早孕作用是通过局部肾上腺素能和5-羟色胺能机制。优、利宫腔给药安全范围较大(治疗指数26.5),局部刺激性较小,有可能成为一种近乎生理的终止早期妊娠的新方法。
There were 130 embryos in early pregnancy in rabbits, which were divided into 4 groups. Intrauterine injection of gavagenz (optimal) 6mg and / or reserpine (gavage) 0.19mg, termination rate of pregnancy: control group 7.7%, gifted group 12.0% Lee group 19.3%, Youli sequential administration group 89.6%, showed a significant synergistic effect (P <0.001). If the excellent, the total amount of intravenous injection, embryo mortality was only 23.2%. Pre-intravenous injection of phenoxybenzamine, can make excellent, uterine delivery of anti-pregnancy effect reduced to 46.1%. Description excellent, Lee anti-early pregnancy effect is through the local adrenergic and serotoninergic mechanisms. Uterine cavity delivery of a large safe range (treatment index 26.5), local irritation smaller, may become a near physiological termination of early pregnancy new method.