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营养性巨幼细胞性贫血(NMA)和上消化道癌在山西均较常见。关于叶酸缺乏和癌的发生之间的关系迄今论述颇多。Sutherland等(1983)论述了叶酸缺乏可导致染色体脆断片的形成。叶酸敏感型染色体脆断部位占目前所知人类基因组21个脆弱部位的14个,而染色体脆弱部位既可能为恶性肿瘤染色体的重排提供“方便”条件,又可能改变癌基因的活性,43％的脆弱部位点与肿瘤相关性染色体畸变位点相重叠。Butterworth等(1982)报道口服避孕药的妇女其宫
Nutritional megaloblastic anemia (NMA) and upper gastrointestinal cancer are more common in Shanxi. The relationship between folic acid deficiency and the occurrence of cancer has so far discussed a lot. Sutherland et al. (1983) demonstrated that folate deficiency can lead to the formation of chromosomal fragmentation. Fragile parts of folic acid-sensitive chromosomes accounted for 14 of the 21 vulnerable parts of the human genome at present, while the fragile parts of the chromosomes may provide “convenient” conditions for the rearrangement of malignant tumor chromosomes, may also change oncogene activity, and 43% Of the vulnerable sites and tumor-associated chromosomal aberration sites overlap. Butterworth et al (1982) reported oral contraceptives in women’s womb