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Objective: Fluoroscopy guidance is generally required for endobronchial ultrasonography with guide sheath (EBUS-GS) in peripheral pulmonary lesions (PPLs).Virtual bronchoscopic navigation (VBN) can guide the bronchoscope by creating virtual images of the bronchial route to the lesion.The diagnostic yield and safety profiles of VBN without fluoroscopy for PPLs have not been evaluated in inexperienced pulmonologist performing EBUS-GS.Methods: Between January 2016 and June 2017,consecutive patients with PPLs referred for EBUS-GS at a single cancer center were enrolled.The diagnostic yield as well as safety profiles was retrospectively analyzed,and our preliminary experience was shared.Results: A total of 109 patients with 109 lesions were included,99 (90.8％) lesions were visible on EBUS imaging.According to the procedure time needed to locate the lesion on EBUS,24.8％ (27/109) were deemed technically difficult procedures;however,no significant relationships were identified between candidate parameters and technically diffieult procedures.The overall diagnosis yield was 74.3％ (81/109),and the diagnostic yield of mahgnancy was 83.7％ (77/92).Lesions larger than 20 mm[odds ratio (OR),2.758;95％ confidence interval (95％ CI),1.077-7.062;P=0.034]and probe of within type (OR,3.174;95％ CI,1.151-8.757,P=0.026) were independent factors leading to a better diagnostic yield in multivariate analysis.About 30 practice procedures were needed to achieve a stable diagnostic yield,and the proportion of technically difficult procedures decreased and stabilized after 70 practice procedures.Regarding complications,one patient (0.9％) had intraoperative hemorrhage (100 mL) which was managed under endoscopy.Conclusions: VBN without fluoroscopy guidance is still useful and safe for PPLs diagnosis,especially for malignant diseases when performed by pulmonologist without previous experience of EBUS-GS.VBN may simplify the process of lesion positioning and further multi-center randomized studies are warranted.