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目的:研究健骨活血丸对骨性关节炎模型兔关节液和血清中TNF-α表达的影响。方法:采用Hulth造模法建立OA模型,造模后肌注青霉素1周,预防感染,4周后灌胃,6周后取关节液和血清,测定TNF-α水平。结果:中药组关节液和血清中TNF-α明显低于对照组,差异有统计学意义,(P<0.01)。结论:中药健骨活血丸对骨性关节炎兔关节液和血清中TNF-α表达有明显的抑制作用,对骨性关节炎有良好的治疗作用。
Objective: To study the effect of Jianguhuoxue Pill on the expression of TNF-α in synovial fluid and serum of rabbits with osteoarthritis. Methods: The OA model was established by Hulth modeling. After the model was made, penicillin was injected intramuscularly for 1 week to prevent infection. After 4 weeks, the synovial fluid and serum were taken and the level of TNF-α was determined. Results: The levels of TNF-α in the synovial fluid and serum of the TCM group were significantly lower than those of the control group (P <0.01). CONCLUSION: Jianguhuoxue Pill has obvious inhibitory effect on the expression of TNF-α in the synovial fluid and serum of rabbits with osteoarthritis, and has a good therapeutic effect on osteoarthritis.