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多毛妇女中2％～5％为高雄激素耐胰岛素黑棘皮(HAIR-AN)综合征。对其治疗反应尚不明。本文报道5例HAIR-AN综合征患者采用口服避孕药(OC)治疗的效果及无效者随后用促性腺激素释放激素增效剂(GnRHa)抑制的效果。 5例患者年龄14～17岁。体重指数25.4-41.7、多毛评分为8～18。血总睾酮(T)74～832ng/d1,游离T(FT)0.8～4.2ng/d1,性激素结合球蛋白(SHBG)130～150nmol/L,去氢表雄酮硫酸盐(Ds)589～5633ng/ml,胰岛素基值14～150μU
2% to 5% of hirsutism women are Kaohsiung Hormone Resistance Insulin-Acrosinosa (HAIR-AN) Syndrome. The response to treatment is not known. This article reports the efficacy of oral contraceptives (OC) in 5 patients with HAIR-AN syndrome and the subsequent suppression by ineffective gonadotropin-releasing hormone potentiators (GnRHa). 5 patients aged 14 to 17 years old. Body mass index 25.4-41.7, hairy score of 8 to 18. Blood total testosterone (T) 74 ~ 832ng / d1 free T (FT) 0.8 ~ 4.2ng / d1, sex hormone binding globulin SHBG 130 ~ 150nmol / L, dehydroepiandrosterone sulfate 589 ~ 5633ng / ml, insulin base value 14 ~ 150μU