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目的探讨第三方脐血输注中不良反应的发生现状及其相关因素。方法 2013年1月—2015年12月,调查苏州市某三级甲等医院血液造血干细胞移植中心成功实施单倍体造血干细胞移植联合第三方脐血输注的305例恶性血液病患者,采用一般资料调查表及第三方脐血输注不良反应调查表收集资料。结果第三方脐血输注中不良反应发生率为49.51%,以心血管系统不良反应为主(82.78%),其中高血压发生率最高,为77.48%。引起不良反应发生的主要原因为年龄、脐血供受体人类白细胞抗原配型相合度、复苏脐血细胞活力。结论临床护理人员应对年龄较大,脐血供受体人类白细胞抗原配型相合度低,输注复苏脐血细胞活力高的单倍体造血干细胞移植联合第三方脐血输注的患者在干细胞输注期间加强监护,及时给予预见性护理。
Objective To investigate the occurrence and related factors of adverse reactions in third party cord blood transfusion. Methods From January 2013 to December 2015, 305 patients with hematologic malignancies who underwent haploidentical hematopoietic stem cell transplantation combined with third-party umbilical cord blood transfusion were investigated in a hematopoietic stem cell transplantation center of a tertiary hospital in Suzhou. Data questionnaire and third-party investigation of adverse reactions of cord blood transfusion questionnaire to collect data. Results The incidence of adverse reactions in third party cord blood transfusions was 49.51%, mainly cardiovascular adverse reactions (82.78%), of which the highest incidence of hypertension was 77.48%. The main causes of adverse reactions are age, cord blood donor receptor HLA matching, recovery of cord blood cell viability. Conclusions The clinical nurses should cope with haploidentical hematopoietic stem cell transplantation combined with third-party cord blood transfusions in older patients, with low compatibility of cord blood donor HLA-DR, During the strengthening of custody, the timely provision of predictive care.