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观察不同剂量铝(40、100mg/kg)、不同时间阶段在大鼠各组织中的贮留、分布及48h尿、粪中排泄量。结果表明,高剂量铝组24、48h表现吸收率为19.07％～19.45％和3.50％～7.72％,表观贮留率为16.89％～20.67％和1.70％～6.54％,均显著低于低剂量组24、48h的表观吸收率(29.40％～36.58％和3.76％～13.48％)和表观贮留率(为29.27％～36.43％和3.69％～13.35％(P<0.01或<0.05)。两种剂量铝灌胃后的大鼠肝、肾、脑组织铝量都增加,但随着大鼠尿、粪的排泄,肝、肾铝浓度在一定时间阶段后开始下降,而脑铝含量却增加,且高剂量铝组脑含量显著高于低剂量铝组,差异有极显著意义(P<0.01)。
Observe different doses of aluminum (40, 100mg / kg), at different time stages in the organization of rats in the storage, distribution and 48h urinary excretion. The results showed that the apparent absorption rates of high-dose aluminum 24, 48h were 19.07% -19.45% and 3.50% -7.72%, and the apparent retention rates were 16.89% -20.67% and 1.70% -6.54% The apparent absorptivity (29.40% -36.58% and 3.76% -13.48%) and apparent retention rate (29.27% -36.43% and 3.69% -13.35%, P <0.01 or <0.05) of the 24 and 48h groups, respectively. Aluminum content in rat liver, kidney and brain tissue after two doses of aluminum was increased, but with the excretion of urine and feces of rats, the concentration of aluminum in liver and kidney began to decline after a certain period of time, while the content of brain aluminum (P <0.01), and the brain content of high-dose aluminum group was significantly higher than that of low-dose aluminum group.