儿童特发性肾病综合征约90%对激素是敏感的,但当减量或停药后有半数以上病人会复发,且这些病人常是激素依赖或副作用导致应用其它药物如烷化剂,而这些药物也有副作用。10%的病人对激素治疗是无效的,其中50%以上会发展到终末期肾衰,且激素无效的病人应用烷化剂疗效也不肯定,为此作者应用环孢素A治疗儿童肾病综合征,观察其疗效,并通过重复肾活检来评价其副作用和肾毒性。 About 90% of children with idiopathic nephrotic syndrome are hormone-responsive, but more than half of patients relapse after reduction or discontinuation, and these patients often have hormone dependence or side effects that lead to the use of other drugs such as alkylating agents, These drugs also have side effects. 10% of the patients on the hormone therapy is ineffective, of which more than 50% will develop to end-stage renal failure, and hormone ineffective patients with alkylating agents curative effect is not certain, for which the authors apply cyclosporin A treatment of children with nephrotic syndrome , To observe its curative effect, and to evaluate side effects and nephrotoxicity by repeating renal biopsy.