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目的:观察雾化吸入伊洛前列素溶液对高海拔地区青年的抗低氧效果。方法:将32名受试者随机分为伊洛前列素组(n=16)和对照组(n=16),自海拔1 400m历时5天进入5 200m,从进入海拔5 200m当天开始,伊洛前列素组每天4次雾化吸入伊洛前列素溶液,连续5天;对照组用同样的方法吸入少量生理盐水。随访观察第1天、3天、5天急性高原反应的严重程度、血氧饱和度(SaO2)和心率(HR)。结果:两组青年进入高原后均未发生高原肺水肿和高原脑水肿。进入海拔5 200m第1天、3天、5天伊洛前列素组较对照组急性高原反应分值和HR均降低(P<0.05);SaO2均增高(P<0.001)。结论:在高海拔地区雾化吸入伊洛前列素溶液可改善高原低氧血症,降低急性高原反应的发病率。
Objective: To observe the anti-hypoxic effect of inhaling iloprost solution on young people in high altitude area. Methods: Thirty-two subjects were randomly divided into two groups: the iloprost group (n = 16) and the control group (n = 16) In the loperapilant group, the iloprost solution was inhaled 4 times per day for 5 consecutive days. The control group inhaled a small amount of saline by the same method. The severity of acute altitude sickness, oxygen saturation (SaO2) and heart rate (HR) were observed on the first day, the third day and the fifth day. Results: Both high altitude pulmonary edema and high altitude cerebral edema did not occur in both groups of young people after entering the plateau. The scores of acute altitude sickness and HR were lower in the iloprost group than in the control group on the 1st, 3rd, and 5th days after entering the elevation of 5 200m (P <0.05), and SaO2 both increased (P <0.001). Conclusion: Inhalation of iloprost solution in high altitude area can improve plateau hypoxemia and reduce the incidence of acute altitude sickness.