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目的 :探讨基质金属蛋白酶 9(MMP 9)、组织金属蛋白酶抑制因子 1(TIMP 1)在胃癌中表达的意义。方法 :采用免疫组化S P法对 47例胃癌组织进行MMP 9及TIMP 1的检测。结果 :MMP 9、TIMP 1主要表达于癌周基质细胞 ,癌细胞少量表达 ;MMP 9、TIMP 1表达与胃癌患者淋巴结转移 (P <0 0 1)、浆膜浸润相关 (P <0 0 1) ;TIMP 1的表达与胃癌TNM分期相关 (P <0 0 5 ) ,而MMP 9的表达与胃癌TNM分期无相关性 (P >0 0 5 )。结论 :MMP 9及TIMP 1可作为判断胃癌恶性行为的重要生物学标记物。
Objective: To investigate the expression of matrix metalloproteinase 9 (MMP 9) and tissue inhibitor of metalloproteinase 1 (TIMP 1) in gastric cancer. Methods: Immunohistochemical SP method was used to detect MMP-9 and TIMP-1 in 47 cases of gastric cancer. Results: MMP 9 and TIMP-1 were mainly expressed in pericancerous stromal cells and a small amount of cancer cells. The expressions of MMP 9 and TIMP-1 were correlated with lymph node metastasis (P <0.01) and serosal invasion in gastric cancer (P <0.01) The expression of TIMP-1 was correlated with the TNM staging of gastric cancer (P <0.05), while the expression of MMP-9 was not related with the TNM stage of gastric cancer (P> 0.05). Conclusion: MMP 9 and TIMP-1 can be used as important biomarkers to judge the malignant behavior of gastric cancer.