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本文观察了1例急性粒细胞白血病,其白血病前期病程长达12年最终发展为白血病的全过程。该例临床特征为贫血、出血或同时存在。同时对三种血细胞成分在病程不同阶段进行了动态观察。讨论了血液形态学异常的改变。还对CFU-C干细胞培养染色体核型及姐妹染色单体互换(SCE)的频率和PK酶活性等作了观察,这些检查项目有助于鉴别诊断。
This article observed a case of acute myeloid leukemia, the leukemia course of up to 12 years eventually develop the whole process of leukemia. The clinical features of this case are anemia, bleeding or both. At the same time, the three blood cell components in the different stages of the course of the dynamic observation. Discussed changes in abnormal blood morphology. CFU-C stem cell culture chromosome karyotype and sister chromatid exchange (SCE) frequency and PK enzyme activity were also observed, these tests will help the differential diagnosis.