论文部分内容阅读
观察２４例急性心肌梗塞（ＡＭＩ）患者的血清脂蛋白（ａ）［Ｌｐ（ａ）］动态变化及其与静脉法溶栓疗效关系。结果表明，ＡＭＩ患者的Ｌｐ（ａ）呈一过性升高，７～１４天达峰值，溶栓组比对照组峰值较快降至基线水平。Ｌｐ（ａ）浓度在溶栓不成功、住院期死亡或梗塞范围大的患者中增高更为明显，提示Ｌｐ（ａ）水平变化与ＡＭＩ溶栓疗效及急性期预后间可能有一定的联系。另外，还发现ＡＭＩ发病后早期组织型纤溶酶原激活物（ｔ－ＰＡ）活性及纤溶蛋白原溶解活性下降、纤溶酶原激活物抑制物（ＰＡＩ）活性升高；静脉滴注尿激酶或去纤酶后均可使ｔ－ＰＡ和纤溶活性升高，而且用药后第１～３天还使ＰＡＩ活性及纤维蛋白原含量明显降低，Ｌｐ（ａ）、血脂及纤溶指标相互之间相关性不甚明显。
To investigate the dynamic changes of serum lipoprotein (a) [Lp (a)] in 24 patients with acute myocardial infarction (AMI) and its relationship with thrombolytic efficacy of venous thrombosis. The results showed that in patients with AMI, Lp (a) increased transiently and peaked at 7 to 14 days. The peak value of thrombolytic group was lower than that of control group to baseline level. Lp (a) concentration in patients with unsuccessful thrombolysis, in-hospital mortality or infarct size increased more significantly, suggesting that changes in Lp (a) AMI thrombolytic efficacy and prognosis may be related to a certain degree. In addition, the activity of early tissue-type plasminogen activator (t-PA) and plasminogen activator (PAI) activity and the activity of plasminogen activator inhibitor (PAI) were also decreased after AMI onset. Intravenous drip urine The activity of t-PA and fibrinolytic activity were increased after both kinases and defibrillators, and PAI activity and fibrinogen content were also significantly decreased from day 1 to day 3 after administration. Lp (a), lipids and fibrinolysis The correlation is not obvious.