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以对硝基苯甲酸为起始原料,改进了对甲胺基苯甲酰谷氨酸二钠的合成工艺,总收率由原工艺的12%提高到31%,降低了合成甲氨蝶呤的成本。
Using p-nitrobenzoic acid as starting material, the synthesis of disodium methylaminobenzoyl glutamate was improved. The overall yield was increased from 12% to 31% of the original process, which reduced the synthesis of methotrexate the cost of.