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多药耐药性(multidrug resistance,MDR)即肿瘤细胞对一种抗肿瘤药物产生耐药性的同时,对结构和作用机制不同的抗肿瘤药物产生交叉耐药性。习惯上将能逆转多药耐药性的药物,称为多药耐药性逆转剂(MDR reversing agents)或化疗增敏剂(chemosensiuzer,CS)。目前发现的CS为数不少,但传统的逆转剂临床应用却大受限制,除其疗效尚不肯定外,主要是存在严重的不良反应,使病人难以耐受。天然药物资源丰富,其中具有肯定抗肿瘤作用者已不下百种,而近年来研究表明一些天然药物在很低浓度时具有MDR逆
Multidrug resistance (MDR) means that tumor cells produce resistance to an anti-tumor drug and cross-resistance to antitumor drugs with different structures and mechanisms. Drugs that are habitually capable of reversing multidrug resistance are called MDR reversing agents or chemosensiuzer (CS). At present, there are many CSs found, but the clinical application of traditional reversal agents is greatly limited. In addition to its efficacy is not yet certain, there are mainly serious adverse reactions, making patients difficult to tolerate. Natural medicine is rich in resources, among which there are no fewer than 100 species with affirmative anti-tumor effects. In recent years, studies have shown that some natural medicines have MDR at very low concentrations.