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作者报道9个国家16个单位按随机分组双盲法,应用左旋咪唑治疗类风湿性关节炎的协作研究结果。本文363例中完成6个月观察期的264例,将其分3组:持续治疗组86例,间歇治疗组93例,对照组85例。左旋咪唑的剂量为:第一周,50mg每日1次,第二周,50 mg每日2次;第三周起50 mg,每日3次。持续治疗组,每天服药。间歇治疗组,每周服药3天。对照组只服安慰剂。在观察期内病人可以继续服用原来使用的止痛剂和抗炎药物,但禁用保太松类药物,皮质激素不能超过相当于强的松龙10mg/日的剂量。
The authors report that 16 units from 9 countries were randomized to double-blind, collaborative study of levamisole for the treatment of rheumatoid arthritis. This article 363 cases to complete the 6-month observation period in 264 cases, divided into 3 groups: continuous treatment group of 86 cases, intermittent treatment group of 93 cases, control group of 85 cases. Levamisole dose: the first week, 50mg once daily, the second week, 50 mg twice daily; third week 50 mg, 3 times daily. Continued treatment group, taking medicine daily. Intermittent treatment group, taking 3 days a week. The control group was given placebo only. In the observation period the patient can continue to take the original use of analgesics and anti-inflammatory drugs, but the banned Paulisone drugs, corticosteroids can not exceed the dose of prednisolone 10mg / day.