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目的探讨彻底病灶清除术后I期植骨与抗生素灌洗引流治疗慢性骨髓炎的临床疗效。方法对22例慢性骨髓炎患者行彻底病灶清除术，术中I期自体骨植骨，并依据细菌培养和药物敏感试验结果，联和敏感抗生素溶液置管行闭式持续灌洗负压引流术治疗。结果22例患者中，21例(95.5豫)感染治愈并获得骨愈合；1例(4.5豫)患者感染复发。随访时间1.5个月~5年,平均3.25年。结论骨髓炎病灶彻底清除术后，I期植骨联合抗生素溶液持续灌洗负压引流术治疗，可以获得95豫以上的术后感染治愈率及骨性愈合率，近远期疗效稳定。是根治骨髓炎的有效临床方法。“,”Objective To investigate the thorough debridement of the lesion after one-stage bone grafting and antibiotic lavage clinical ef icacy in the treatment of chronic osteomyelitis. Methods 22 cases of chronic osteomyelitis patients underwent thorough debridement, intraoperative one-stage bone grafting, and on the basis of bacterial culture and drug sensitivity test results, and the sensitive antibiotic solution catheter for closed negative pressure drainage in the treatment of continuous ir igation. Results The 22 patients, 21 cases (95.5%) infection is cured and obtained bone healing; 1 cases (4.5%) of patients with recur ent infection. Fol ow up of 1.5 months to 5 years, average 3.25 years. Conclusion Postoperative osteomyelitis radical debridement, I combined with bone graft for treatment of antibiotic solution lavage continuous negative pressure drainage, can cure rate and bone healing rate of postoperative infection for more than 95%, stable short term and long term ef ect. Is an ef ective clinical method of radical osteomyelitis.