198 6年Sen和Baltimore首先从B淋巴细胞核取提物中检测到一种能与免疫球蛋白κ轻链基因增强子κB序列(GCGACTTTC)特异结合的核蛋白 ,此后发现它能与某些基因的增强子上B位点结合 ,从而启动及促进相应基因转录 ,故把这类蛋白分子统称为NF κB[1] 。研究发现NF κB具有广泛生物学 In 1993, Sen and Baltimore first detected a nuclear protein that specifically binds to the immunoglobulin κ light chain gene enhancer κB sequence (GCGACTTTC) from the B lymphocyte nuclear extracts. It was subsequently found that it interacts with some genes Enhancer binding site B, thus initiating and promoting the corresponding gene transcription, so these protein molecules collectively referred to as NF κB [1]. The study found that NF κB has a wide range of biology