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皮肤最外层的表皮是由处于不同分化阶段的表皮细胞所构成.脂质是皮肤渗透性的重要决定因素,表皮的脂质部分约占其总重量的5%左右.在有病变的皮肤中,如伴性遗传的鱼鳞病、Refsun氏病和中性脂肪代谢性疾病中,分化过程发生改变导致表皮上层变薄或变厚.这种“不正常”的表皮上层脂质含量也不正常,并且伴有细胞间粘附性的改变.由于细胞的胆固醇含量似乎在表皮细胞间的粘附性中起重要作用,并决定了表皮细胞的渗透性,作者用~(14)C放射标记的醋酸盐和锌酸盐掺入到胆固醇中的
The epidermis of the outermost layer of the skin is composed of epidermal cells at different stages of differentiation Lipid is an important determinant of skin permeability and the lipid portion of the epidermis accounts for about 5% of its total weight In diseased skin , Such as sex-linked ichthyosis, Refsun’s disease, and neutral lipodystrophy, changes in the differentiation process lead to thinning or thickening of the upper epidermis. This “abnormal” upper epidermal lipid content is also not Normal and accompanied by changes in cell-cell adhesion.As the cellular cholesterol content appears to play an important role in epidermal cell adhesion and determines the permeability of epidermal cells, the authors used ~ (14) C radiolabeling Of the acetate and zincate incorporated into the cholesterol