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目的:观察氟康唑联合定君生治疗复发性外阴阴道假丝酵母茵病的临床疗效。方法:将2011年9月至2013年9月收治的复发性外阴阴道假丝酵母茵病患者随机分为治疗组(102例)和对照组(102例)。治疗组于月经1、4 d顿服氟康唑150 mg/d,月经干净后定君生塞阴道10 d:对照组仅于月经干净后定君生塞阴道10 d.连续使用3个月经周期。治疗结束后即刻与治疗结束后1个月观察两组的疗效。结果:治疗组治愈90例、好转10例、无效2例,总有效率为98.0%;对照组治愈72例、好转18例、无效12例,总有效率为88.2%;两组总有效率比较,差异有统计学意义(P<0.05)。治疗组治疗完成后1个月复发6例,复发率为6.0%(6/100);对照组复发13例,复发率为14.%(13/90),两组比较,差异有统计学意义(P<0.05)。结论:氟康唑联合定君生治疗外阴阴道假丝酵母茵病疗效显著,值得临床推广。
Objective: To observe the clinical efficacy of fluconazole combined with Ding Jun Sheng in treating recurrent vulvovaginal candidiasis. Methods: The patients with recurrent vulvovaginal candidal yin from September 2011 to September 2013 were randomly divided into treatment group (102 cases) and control group (102 cases). The treatment group in the menstrual 1,4 D Dayton fluconazole 150 mg / d, menstruation clean after the monarch plug Cypriot vaginal 10 d: the control group only after menstruation clean Jun constant plug vaginal 10 d continuous use of three menstrual cycles . Immediately after the end of treatment and 1 month after the end of treatment observed the efficacy of both groups. Results: In the treatment group, 90 cases were cured, 10 cases were improved, 2 cases were ineffective, and the total effective rate was 98.0%. In the control group, 72 cases were cured, 18 cases improved, 12 cases were ineffective, and the total effective rate was 88.2%. , The difference was statistically significant (P <0.05). In the treatment group, 6 cases relapsed 6 months after the completion of treatment, with a recurrence rate of 6.0% (6/100). In the control group, 13 cases relapsed, the recurrence rate was 14% (13/90). There was significant difference between the two groups (P <0.05). Conclusion: Fluconazole combined with Ding Jun Sheng treatment of vulvovaginal candidiasis Yin significant effect, worthy of clinical promotion.