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目的 研究大鼠脑缺血时脑细胞胞浆酶含量变化的影响。方法 采用全自动生化分析仪检测血清肌酸激酶 (CK)、肌酸激酶脑型同工酶 (CK-BB)、乳酸脱氢酶 (L DH)以及天门冬氨酸氨基转换酶 (AST)的含量。结果 大鼠脑缺血 2 0 min,血中 CK、CK-BB和 L DH的含量明显高于假手术组 (P<0 .0 5或 P<0 .0 1) ;脑缺血 6 0 min和 12 0 min,血中 CK、CK-BB、LDH和 AST的含量均明显高于假手术组 (P<0 .0 1)。结论 脑缺血时血中胞浆酶的活性增加 ,可用来判断细胞膜受损伤的程度
Aim To study the effect of changes of cytoplasmic enzyme in brain cells during cerebral ischemia in rats. Methods Serum creatine kinase (CK), creatine kinase (CK-BB), lactate dehydrogenase (L DH) and aspartate aminotransferase (AST) were detected by automatic biochemical analyzer content. Results The content of CK, CK-BB and L DH in the cerebral ischemia group were significantly higher than those in sham group (P0.05 or P0.01) at 60 min after cerebral ischemia And 12 0 min, the contents of CK, CK-BB, LDH and AST in blood were significantly higher than those in sham operation group (P <0.01). Conclusion The activity of cytoplasmic enzyme in cerebral ischemia increases, which can be used to judge the degree of injury of cell membrane