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脑膜炎双球菌感染是儿童与青少年感染死亡的最常见因素,可引起10％的感染者与30％感染性休克者死亡。 目前认为,脑膜炎双球菌引起脓毒症与脑膜炎,导致血管、组织器官的损害与内毒素激活宿主的炎症通道有关,因而控制循环中的内毒素可改善疾病的病变程度与预后。一种经修饰N端片段的重组21kDa人BPI(rBPI_(21))可与多种致病菌(包括脑膜炎双球菌)内毒素紧密结合并将内毒素中和。本文主要报道严重脑膜炎双球菌脓毒症患儿用
Meningococcal infection is the most common cause of death in children and adolescents and can cause death in 10% of infected and 30% of septic shock. At present, it is thought that meningococcus causes meningitis and meningitis, resulting in the damage of blood vessels and tissues and organs, and the inflammatory pathways activated by endotoxin in the host. Therefore, controlling the circulating endotoxin can improve the degree and prognosis of the disease. A modified 21 kDa human BPI (rBPI_ (21)) modified with an N-terminal fragment was found to bind tightly to endotoxins of various pathogenic bacteria including meningococcus and endotoxin neutralization. This article mainly reports severe meningococcal sepsis in children