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目的：探讨p21蛋白及nm23蛋白的表达与大肠癌临床生物学行为的关系及其临床实用价值。方法：采用免疫组织化学方法（LSAB）分别对206例大肠癌标本进行p21蛋白和nm23蛋白表达的检测、分析。结果：大肠癌p21蛋白的表达与nm23蛋白的表达无明显相关性（r＝-0．1536）。p21蛋白及nm23蛋白的表达与病人年龄、性别、肿瘤部位、大体类型、组织类型、Dukes’分期等无关（P＞0．05）；与病人预后明显相关（P＜0．01），即p21表达越高病人预后越差，而nm23蛋白的表达越高则病人预后越好。结论：大肠癌p21蛋白的异常表达与nm23蛋白的表达紊乱无明显相关性，p21蛋白和nm23蛋白表达的检测有助于大肠癌的临床诊断及预后的评估。
Objective: To investigate the relationship between the expression of p21 protein and nm23 protein and the clinical biological behavior of colorectal cancer and its clinical value. Methods: The expression of p21 protein and nm23 protein in 206 colorectal cancer specimens were detected and analyzed by immunohistochemical method (LSAB). Results: There was no significant correlation between the expression of p21 protein and nm23 protein in colorectal cancer (r=-0.1536). The expression of p21 protein and nm23 protein was not related to the patient’s age, gender, tumor location, gross type, tissue type, Dukes’ stage, etc. (P>0.05); it was significantly related to the prognosis of patients (P<0.01), ie p21 The higher the expression, the worse the patient’s prognosis, and the higher the expression of nm23 protein, the better the patient’s prognosis. Conclusion: The abnormal expression of p21 protein in colorectal cancer has no correlation with the disorder of nm23 protein expression. The detection of p21 protein and nm23 protein is helpful for clinical diagnosis and prognosis evaluation of colorectal cancer.