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近年来,发现和证实钙拮抗剂(CA,也称钙通道阻滞剂)对肾脏有利。本文就CA对肾脏疾病防治的实验研究成果和临床应用研究情况作一综述。 CA对肾病保护的实验研究 (一)降高血压和改善肾脏血流动力学这是CA最突出的作用.它能明显地改变肾脏对缩血管因素的反应,而不影响已扩张的血管,从而维持肾脏血流量。体外灌注表明,CA可使大鼠肾脏的血管阻力降低;当存在
In recent years, calcium antagonists (CA, also known as calcium channel blockers) have been found to be beneficial to the kidney. This article reviews the experimental research and clinical application of CA on renal disease prevention and treatment. Experimental Study on the Protection of Nephropathy by CA 1. Lowering Blood Pressure and Improving Renal Hemodynamics This is the most prominent role of CA. It can significantly change the renal response to vasoconstrictor effects without affecting the dilated blood vessels and thus Maintain renal blood flow. In vitro perfusion shows that CA decreases vascular resistance in rat kidneys; when present