论文部分内容阅读
目的探讨甲钴胺分散片联合还原型谷胱甘肽对肺癌化疗患者神经毒性反应的防治效果。方法选取2015年1月至2016年6月间广东省江门市中心医院收治的84例肺癌化疗患者,采用随机数表法分为观察组和对照组,每组42例。观察组患者行甲钴胺分散片联合还原型谷胱甘肽注射液治疗,对照组患者行还原型谷胱甘肽注射液治疗。采用Levi专用感觉神经毒性分级,分别观察两组肺癌化疗患者接受化疗4、6个周期时神经毒性反应的发生率。患者治疗6个周期时,分析甲钴胺联合谷胱甘肽对降低肺癌化疗患者神经毒性反应的总有效率。结果观察组患者急性神经毒性反应发生率高于对照组患者,均为诱发的肢端麻木,两组比较,差异无统计学意义(P>0.05)。接受化疗4、6个周期后,观察组患者0级神经毒性反应发生率(61.9%)明显高于对照组(33.3%),观察组患者1~3级神经毒性反应发生率明显低于对照组,差异均有统计学意义(均P<0.05)。观察组患者接受化疗6周期时,降低神经毒性反应总有效率为90.5%,明显高于对照组的78.6%,差异有统计学意义(P<0.05)。结论甲钴胺联合还原型谷胱甘肽可有效降低肺癌化疗患者慢性神经毒性反应发生率,提高临床治疗有效率,对肺癌化疗患者发生神经毒性反应具有较高的防治价值,值得临床推广。
Objective To investigate the preventive and therapeutic effects of mecobalamin dispersible tablets combined with reduced glutathione on the neurotoxicity of patients with lung cancer undergoing chemotherapy. Methods From January 2015 to June 2016, 84 patients with lung cancer who were treated in Jiangmen Central Hospital of Guangdong Province were divided into observation group and control group with random number table, with 42 cases in each group. Patients in the observation group were treated with mecobalamin dispersible tablets combined with reduced glutathione injection, and patients in the control group were treated with reduced glutathione injection. Levi special neurosensory grade was used to observe the incidence of neurotoxic reactions in 4 and 6 cycles of chemotherapy in two groups of patients with lung cancer. The patient’s treatment of six cycles, the analysis of mecobalamin combined with glutathione to reduce the overall response rate of patients with lung cancer chemotherapy-induced neurotoxicity. Results The incidence of acute neurotoxic reaction in observation group was higher than that in control group, all of them were induced numbness of limbs. There was no significant difference between the two groups (P> 0.05). After 4 and 6 cycles of chemotherapy, the incidence of grade 0 neurotoxic reaction in observation group (61.9%) was significantly higher than that in control group (33.3%). The incidence of neurotoxic reactions of grade 1 to 3 in observation group was significantly lower than that in control group , The differences were statistically significant (all P <0.05). In the observation group, the total effective rate of reducing neurotoxicity was 90.5% when receiving 6 cycles of chemotherapy, which was significantly higher than that of the control group (78.6%, P <0.05). Conclusions Mecobalamin combined with reduced glutathione can effectively reduce the incidence of chronic neurotoxic reactions in patients with lung cancer and improve the efficiency of clinical treatment. It has a high value in prevention and treatment of neurotoxicity in patients with lung cancer and is worthy of clinical promotion.