关于流行性出血热(简称流热)的发病机理与免疫反应关系的研究国外罕见。国内一些学者在登革热免疫学发病机理研究启示下,经过几年的实验研究发现病人有免疫功能紊乱,在循环血液中和肾小球基底膜均检出免疫复合物(1—4),并证明有补体传统途径明显地激活。鉴于这些免疫学改变与病程经过、临床症状严重性有一定的相关性,因而,一些学者提出免疫复合物学说,他们认为本病的发病机理是免疫复合物引起的免疫病理损伤,发病的始动环节是 Research on the relationship between the pathogenesis and immune response of epidemic hemorrhagic fever (referred to as fluid heat) is rare abroad. Inspired by the research on the pathogenesis of dengue immunology, some domestic scholars have found that patients have immune dysfunction after several years of experimental research, and immune complexes are detected both in the circulating blood and in the glomerular basement membrane (1-4) The traditional way of complement is obviously activated. In view of these immunological changes and the course of the disease, the severity of clinical symptoms have some relevance, therefore, some scholars put forward the immune complex theory, they believe that the pathogenesis of this disease is caused by immunocomplex immune pathological damage, the onset of the disease The link is