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对胃肠道癌术后２３例腹腔内化疗（腹腔组）与３２例静脉化疗（静脉组）所致的毒性反应比较分析。腹腔组给予ＤＤＰ３０～６０ｍｇ／Ｍ２，５－ＦＵ１～２ｇ／Ｍ２，加入１Ｌ生理盐水，通过药泵滴入腹腔。静脉组给予ＤＤＰ２０～２５ｍｇ／Ｍ２，５－ＦＵ０５～０７５ｇ／Ｍ２，部分病例加用ＭＭＣ２～４ｍｇ／Ｍ２静注。结果显示，腹腔组出现腹胀较静脉组多，而恶心、呕吐，周围静脉炎，肝、肾功能异常，骨髓抑制等较少、较轻。腹痛、耳鸣及听力下降两组差异无显著性意义。说明腹腔内给药化疗毒性反应少且轻，是一安全的给药途径。
A comparative analysis of the toxicities of 23 cases of gastrointestinal cancer after intraperitoneal chemotherapy (abdominal group) and 32 cases of intravenous chemotherapy (intravenous group). In the peritoneal group, 30 to 60 mg/M2 of DDP and 1 to 2 g/M2 of 5-FU were added, and 1 L of normal saline was added to the abdominal cavity through a drug pump. In the intravenous group, 20 to 25 mg/M2 of DDP was administered, and 5 to 55 mg/M2 of 5-FU was added. In some cases, intravenous injection of MMC 2 to 4 mg/M2 was added. The results showed that there were more bloating in the abdominal cavity group than in the vein group, and nausea, vomiting, peripheral phlebitis, abnormal liver and kidney function, and bone marrow suppression were less and lighter. There was no significant difference in abdominal pain, tinnitus and hearing loss between the two groups. This shows that intraperitoneal administration of chemotherapy is less toxic and less toxic, and is a safe route of administration.