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目的:观察益智宁神液治疗抽动秽语综合征及伴发行为障碍的疗效和安全性。方法:将104例患儿随机分为治疗组和对照组各52例,治疗组采用益智宁神液治疗,对照组采用泰必利治疗,比较2组临床疗效、治疗伴发行为障碍疗效、中医证候改善情况、持续疗效、副反应的发生等。结果:治疗12周后,治疗组运动抽动、发声抽动、综合损害、总抽动程度总有效率分别与对照组比较,差异均有非常显著性意义(P<0.01)。治疗组治疗后注意缺陷多动障碍评分与对照组比较,差异有非常显著性意义(P<0.01)。治疗后治疗组能显著改善抽动秽语综合征患儿的五心烦热、烦躁易怒、面色异常、睡眠障碍、健忘、出汗异常等症状,与对照组比较,治疗组中医证候评分改善更显著,差异有非常显著性意义(P<0.01)。随访半年后,治疗组中医证候评分仍然明显低于对照组,2组比较,差异有非常显著性意义(P<0.01)。随访半年后,治疗组运动抽动、发声抽动、综合损害、总抽动程度总有效率分别与对照组比较,差异均有非常显著性意义(P<0.01)。结论:益智宁神液为治疗抽动秽语综合征及伴发行为障碍有效而安全性较高的一种药物。
Objective: To observe the curative effect and safety of Yizhining Ninh liquid in the treatment of Tourette’s syndrome and associated behavior disorder. Methods: A total of 104 children were randomly divided into treatment group (52 cases) and control group (52 cases). The treatment group was treated with Yizhining Ninjuxu, the control group was treated with tiapride, the clinical efficacy was compared between the two groups, TCM syndromes to improve the situation, sustained efficacy, the incidence of side effects. Results: After 12 weeks of treatment, there were significant differences between the treatment group and the control group (P <0.01) after exercise twitching, vocal tics, total damage and total tic level. Compared with the control group, the scores of attention deficit hyperactivity disorder in the treatment group after treatment were significantly different (P <0.01). After treatment, the treatment group can significantly improve the symptom such as five upset and irritability, irritability, abnormal face, sleep disturbance, forgetfulness and sweating in children with Tourette’s syndrome. Compared with the control group, the TCM syndrome score in the treatment group improved more significantly , The difference was very significant (P <0.01). After six months of follow-up, the TCM syndrome score of the treatment group was still significantly lower than that of the control group. There was a significant difference between the two groups (P <0.01). After six months of follow-up, there were significant differences (P <0.01) between the treatment group and the control group in terms of tics, vocal tics, combined injuries and total tic levels. Conclusion: Yizhiningshen Shenye is an effective and safe drug for the treatment of Tourette’s syndrome and associated behavioral disorders.