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β-catenin是Wnt信号通路的核心分子,具有介导细胞黏附及信号转导双重活性功能。Wnt信号通路在调节细胞生长和分化、胚胎发育过程中起重要作用,该通路的持续活化能加快细胞增殖和诱导凋亡抵抗。已有文献报道β-catenin参与促进T细胞在胸腺内的发育,但它与T细胞各亚群的关系以及
β-catenin is the core molecule of Wnt signaling pathway, which has the function of mediating both cell adhesion and signal transduction. The Wnt signaling pathway plays an important role in the regulation of cell growth and differentiation and embryonic development. The sustained activation of this pathway can accelerate cell proliferation and induce apoptosis resistance. It has been reported in the literature that β-catenin is involved in promoting the development of T cells in the thymus, but it is related to the subsets of T cells and