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实验研究西藏芫根提取物的抗缺氧活性。通过建立小鼠常压缺氧模型、急性脑缺血性缺氧模型以及亚硝酸钠中毒模型,以蒸馏水作为空白对照,盐酸普萘洛尔作为阳性对照,观察芫根水、65%乙醇及95%乙醇提取物的10g/kg、15g/kg和20g/kg剂量组对小鼠缺氧的保护作用,同时观察各提取物10g/kg剂量组对红细胞数量和血红蛋白含量的影响。结果表明,芫根水提取物、65%乙醇提取物及95%乙醇提取物均能明显延长模型小鼠在常压缺氧、急性脑缺血性缺氧及亚硝酸钠中毒时的存活时间,并可增加外周血象中红细胞数与血红蛋白含量,显示芫根提取物具有抗缺氧活性。
Experiments were conducted to study the anti-hypoxic activity of Tibetan root extracts. The mouse model of normobaric hypoxia, acute cerebral ischemic hypoxia, and sodium nitrite poisoning were used to establish distilled water as the blank control. Propranolol hydrochloride was used as a positive control to observe root water, 65% ethanol, and 95 The effects of 10%, 15g/kg, and 20g/kg doses of ethanol extracts on the protection of mice against hypoxia, and the effect of 10 g/kg dose of each extract on the number of red blood cells and the hemoglobin content were observed. The results showed that the root water extract, 65% ethanol extract and 95% ethanol extract can significantly prolong the survival time of model mice under normobaric hypoxia, acute cerebral ischemic hypoxia and sodium nitrite poisoning. It can increase the number of red blood cells and hemoglobin in the peripheral blood, indicating that the root extract has anti-hypoxic activity.