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目的：测定和比较含兰索拉唑、克拉霉素和阿莫西林的５日ｔｉｄ疗法和７日ｂｉｄ疗法根除幽门螺杆菌（Ｈ．ｐｙｌｏｒｉ）的疗效。方法：本研究为随机、双盲、对照研究。胃窦和胃体部活检经组织学检查和快速尿素酶试验确诊为Ｈ．ｐｙｌｏ－ｒｉ感染的患者纳入研究。患者分别接受克拉霉素５００ ｍｇ ｔｉｄ、阿莫西林５００ ｍｇ ｔｉｄ和兰索拉唑每日３０ ｍｇ治疗５天（ＬＡＣ５组）或克拉霉素５００ ｍｇ ｂｉｄ、阿莫西林５００ ｍｇ ｂｉｄ和兰索拉唑每日３０ｍｇ治疗７天（ＬＡＣ７组）。治疗结束至少４周后，用组织学检查和快速尿素酶试验评估Ｈ．ｐｙｌｏｒｉ是否成功根除，胃窦和胃体部活检Ｈ．ｐｙｌｏｒｉ阴性定义为Ｈ．ｐｙｌｏｒｉ根除。结果：１０８例患者纳入研究。ＬＡＣ５组有４例患者失访；ＬＡＣ７组２例患者失访，２例患者对药物不能依从。按意图治疗分析，ＬＡＣＳ组的根除率为８５．２％ ［４６／５４，９５％可信区间（ＣＩ）：７２．９％，９３．４％］，ＬＡＣ７组的根除率为８７．０％（４７／５４，９５％ＣＩ： ７５．１％，９４．６％）；按方案分析，ＬＡＣ５组的根除率为９２．０％（４６／５０，９５％ＣＩ： ８０．８％，９７．８％），ＬＡＣ７组的根除率为９４．０?
OBJECTIVE: To determine and compare the efficacy of 5 days tid therapy with lansoprazole, clarithromycin and amoxicillin and 7 days bid therapy in the eradication of H. pylori. METHODS: This study was a randomized, double-blind, controlled study. Antral biopsy and gastric body by histological examination and rapid urease test was diagnosed as H. Patients with pylo-ri infection were enrolled in the study. Patients received either clarithromycin 500 mg tid, amoxicillin 500 mg tid, and lansoprazole 30 mg daily for 5 days (LAC5 group) or clarithromycin 500 mg bid, amoxicillin 500 mg bid, and lanxorab Azole 30 mg daily for 7 days (LAC7 group). After at least 4 weeks after the end of treatment, histological examination and rapid urease test were used to evaluate H. Successful eradication of pylori, gastric and gastric biopsy. Negative pylori is defined as H. Pylori eradication. Results: 108 patients were enrolled in the study. Four patients in LAC5 group were lost to follow-up. Two patients in LAC7 group were lost to follow-up and two patients were unable to comply with the drug. According to the intention-to-treat analysis, the eradication rate was 85.2% [46/54, 95% CI: 72.9%, 93.4%] in the LACS group and 87.0% in the LAC7 group (47/54, 95% CI: 75.1%, 94.6%). According to the protocol analysis, the eradication rate in the LAC5 group was 92.0% (46/50, 95% CI: 80.8%, 97%). 8%), LAC7 group eradication rate was 94.0?