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目的:探讨血管内皮生长因子A(VEGF-A)在食管鳞状细胞癌中的表达及临床意义。方法:收集2009年1月-2010年12月收治的45例食管鳞状细胞癌患者临床资料及病理标本,应用免疫组织化学法检测肿瘤组织VEGF-A表达及微淋巴管密度(MLVD),分析VEGF-A表达与食管鳞癌患者临床病理资料、MLVD及与患者生存期限的关系。结果:1有淋巴结转移的患者VEGF-A表达阳性率为66.67%,明显高于无淋巴结转移患者的38.10%(P<0.05);2 VEGF-A阳性食管鳞状细胞癌患者MLVD为(8.35±2.45)明显高于阴性患者的(5.32±1.44),(P<0.05);3VEGF-A阳性食管鳞状细胞癌患者3年存活率为41.67%明显低于阴性患者的61.90%(P<0.05)。结论:VEGF-A表达在确定早期食管鳞状细胞癌淋巴结转移方面具有一定的应用价值,可以作为评价预后的有效指标。
Objective: To investigate the expression of vascular endothelial growth factor A (VEGF-A) in esophageal squamous cell carcinoma and its clinical significance. Methods: The clinical data and pathological specimens of 45 patients with esophageal squamous cell carcinoma who were treated from January 2009 to December 2010 were collected. The expression of VEGF-A and MLVD in tumor tissue were detected by immunohistochemistry Relationship between VEGF-A expression and clinicopathological data, MLVD and survival time of patients with esophageal squamous cell carcinoma. Results: 1 The positive rate of VEGF-A expression in patients with lymph node metastasis was 66.67%, which was significantly higher than that in patients without lymph node metastasis (38.10%, P <0.05) .2 The MLVD in patients with VEGF-A positive esophageal squamous cell carcinoma was (8.35 ± (P <0.05). The 3-year survival rate of 41 patients with 3-VEGF-A positive esophageal squamous cell carcinoma was 41.67%, which was significantly lower than that of negative patients (61.90% . Conclusion: The expression of VEGF-A has certain value in determining the lymph node metastasis of early esophageal squamous cell carcinoma, which can be used as an effective index to evaluate the prognosis.