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HSV—1和HSV—2能在人的周围神经中潜伏感染。HSV激活所致的临床表现取决于病毒潜伏的部位、类型和宿主的免疫应答能力。HSV感染造成中枢神经系统损害是脑炎和膜膜炎。由于SHV感染在临床上很难识别,故在病人CSF中检测HSV显得更为重要。 虽然使用PCR法已能检测出HSV DNA,但还不能从复发性脑膜炎病人CSF中分离出。作者用免疫印迹分析ELISA法检测病人CSF中特异型抗体,结合PCR法扩增DNA以证实HSV造成良性、复发性、自限性、无菌性脑膜炎的重要性。
HSV-1 and HSV-2 are latent infections in the peripheral nerves of humans. The clinical manifestations resulting from HSV activation depend on the latent site, type of virus and host immune response capacity. Central nervous system damage caused by HSV infection is encephalitis and membranitis. Since SHV infection is clinically indistinguishable, it is even more important to detect HSV in the patient’s CSF. Although HSV DNA has been detected using the PCR method, it has not yet been isolated from patients with recurrent meningitis. The authors used immunoblot analysis of CSF specific antibodies in patients with CSF, combined with PCR amplification of DNA to confirm the HSV cause benign, recurrent, self-limiting, aseptic meningitis.