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目的:探讨洛伐他汀对低密度脂蛋白所致血管内皮功能损伤的保护作用及可能的机制。方法:一次性从大鼠舌下静脉注射天然低密度脂蛋白(n-LDL 4mg/kg),在舌下静脉注射n-LDL之前大鼠腹腔注射洛伐他汀(2或4 mg/kg),每天一次,连续五天,注射n-LDL后48小时检测乙酰胆碱诱导的血管内皮依赖性舒张(EDR)及血清一氧化氮(NO)、丙二醛(MDA)的含量和超氧化物歧化酶(SOD)的活性。结果:一次注射n-LDL导致了EDR、血清NO水平及SOD活性明显降低,MDA的浓度明显增高。预先给予洛伐他汀能明显减轻LDL引起的EDR的抑制和血清NO水平及SOD活性的降低,减少MDA的生成,左旋硝基精氨酸(L-NNA)减弱洛伐他汀对血管内皮 的保护作用。结论:洛伐他汀对LDL损伤的血管内皮具有保护作用,可能与保护内皮依赖性松弛因子和抗氧化作用有关。
Objective: To investigate the protective effect of lovastatin on vascular endothelial dysfunction induced by low density lipoprotein and its possible mechanism. METHODS: Natural low density lipoprotein (n-LDL 4 mg / kg) was injected subcutaneously into the sublingual vein of rats. Lovastatin (2 or 4 mg / kg) was intraperitoneally injected into the sublingual vein before n-LDL injection. The levels of acetylcholine-induced endothelium-dependent relaxation (EDR), serum nitric oxide (NO), malondialdehyde (MDA) and superoxide dismutase (SOD) were measured once daily for five consecutive days at 48 hours after injection of n-LDL SOD) activity. Results: Single injection of n-LDL resulted in EDR, serum NO level and SOD activity were significantly decreased, MDA concentration was significantly increased. Pretreatment with lovastatin can significantly reduce the inhibition of EDR caused by LDL, the decrease of serum NO and the activity of SOD, and the decrease of MDA production. L-NNA attenuates the protective effect of lovastatin on vascular endothelium . Conclusion: Lovastatin has a protective effect on the vascular endothelium induced by LDL, which may be related to the protection of endothelium-dependent relaxing factor and antioxidation.