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OBJECTIVE Epidermal growth factor receptor (EGFR) isdysregulated in many human malignancies and is a potentialtarget for therapeutic intervention, but there is a majordisagreement among researchers about both the frequency andpossible clinical importance of EGFR overexpression in ovariancancer. We investigated the expression and significance of theEGFR mRNA and vascular endothelial growth factor (VEGF)mRNA in ovarian carcinoma.METHODS Reverse transcription polymerase chain reaction(RT-PCR) was employed to determine the expression of EGFRmRNA and VEGF mRNA in 79 ovarian specimen (including15 normal, 13 benign and 51 malignant, from 79 patients). Therelationship between EGFR and VEGF expression was analyzed.RESULTS The positive rates of the expression of EGFR mRNAand VEGF mRNA were significantly higher in the patientswith ovarian carcinoma than those in both the patients withbenign ovarian tumors and in the normal controls. There wascorrelation between EGFR mRNA expression and clinical stages.The positive rate of the expression of EGFR mRNA in Stage Ⅲ-Ⅳ was higher than that in Stage Ⅰ-Ⅱ of ovarian carcinoma (P <0.05). The expression of VEGF mRNA was correlated with theclinical stages and lymph node metastasis. The expression levelsof VEGF mRNA in Stage Ⅲ-Ⅳ and in the group with lymph nodemetastasis were significantly higher than those in Stage Ⅰ-Ⅱ and inthe group without lymph node metastasis, respectively (P < 0.05).The expression of EGFR mRNA was positively correlated with theexpression of VEGF mRNA (r = 0.438, P < 0.05).CONCLUSION The expressions of EGFR mRNA and VEGFmRNA are positively correlated to the occurrence of ovariancarcinoma and its metastasis. The detection of EGFR and VEGFmay be helpful for the targeted chemotherapy.
OBJECTIVE Epidermal growth factor receptor (EGFR) is isdysregulated in many human malignancies and is a potential target for therapeutic intervention, but there is a majordisagreement among researchers about both the frequency and can be clinical importance of EGFR overexpression in ovarian cancer. We investigated the expression and significance of the EGFR mRNA (RT-PCR) was employed to determine the expression of EGFR mRNA and VEGF mRNA in 79 ovarian specimens (including 15 normal, 13 benign and 51 malignant, from 79 patients. Therelationship between EGFR and VEGF expression was analyzed .RESULTS The positive rates of the expression of EGFR mRNA and VEGF mRNA were were higher in the patients with ovarian carcinoma than those in both the patients withbenign ovarian tumors and in the normal controls. There wascorrelation between EGFR mRNA expression and clinical s tages. The positive rate of the expression of EGFR mRNA in Stage III-IV was higher than that in Stage I-II of ovarian carcinoma (P <0.05). The expression of VEGF mRNA was correlated with the clinical stages and lymph node metastasis. Expression levels of VEGF mRNA in Stage III-IV and in the group with lymph nodemetastasis were significantly higher than those in Stage I-II and inthe groups without lymph node metastasis, respectively (P <0.05). The expression of EGFR mRNA was positively correlated with the expression of VEGF mRNA (r = 0.438, P <0.05) .CONCLUSION The expressions of EGFR mRNA and VEGF mRNA are currently correlated with the occurrence of ovarian carcinoma and its metastasis. The detection of EGFR and VEGF can be helpful for the targeted chemotherapy.