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Pancreatic microcirculatory disturbance plays an importantrole in the pathogenesis of acute pancreatitis,and itinvolves a aeries of changes including vasoconstriction,ischaemia,increased vascular permeability,impairment ofnutritive tissue perfusion,ischaemia/reperfusion,leukocyteadherence,hemorrheological changes and impairedlymphatic drainage.Ischaemia possibly acts as an initiatingfactor of pancreatic microcirculatory injury in acutepancreatitis,or as an aggravating/continuing mechanism.The end-artery feature of the intralobular arterioles suggeststhat the pancreatic microcirculation is highly susceptible toischaemia.Various vasoactive mediators,as bradykinin,platelet activating factor,endothelin and nitric oxideparticipate in the development of microcirculatory failure.
Pancreatic microcirculatory disturbance plays an importantrole in the pathogenesis of acute pancreatitis, and itinvolves a aeries of changes including vasoconstriction, ischaemia, increased vascular permeability, impairment of nutrient tissue perfusion, ischaemia / reperfusion, leukocyteadherence, hemorrheological changes and impairedlymphatic drainage. Ischaemia possibly acts as an initiating factor of pancreatic microcirculatory injury in acute pancreatitis, or as an aggravating / continuing mechanism. The end-artery feature of the intralobular arterioles suggest that the pancreatic microcirculation is highly susceptible to ischaemia. Verious vasoactive mediators, as bradykinin, platelet activating factor, endothelin and nitric oxideparticipate in the development of microcirculatory failure