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目的观察他克莫司(TAC)治疗激素抵抗性肾病综合征(SRNS)的应用效果。方法对24例患者进行前瞻性研究,将其分为观察组和对照组,每组12例。对照组使用激素治疗,观察组应用激素与TAC联合治疗。定期对患者随访,监测2组患者24 h尿蛋白、肝肾功能等指标,观察2组临床疗效。结果治疗后,观察组24 h尿蛋白、白蛋白数值较治疗前均改善,与对照组比较差异有统计学意义(P<0.05)。观察组治疗总有效率为100.00%,高于对照组的66.67%(P<0.05)。结论较高浓度的TAC能更快缓解SRNS,疗效确切,值得进一步研究应用。
Objective To observe the effect of Tacrolimus (TAC) on steroid-resistant nephrotic syndrome (SRNS). Methods 24 patients were prospectively studied, divided into observation group and control group, 12 cases in each group. The control group used hormonal therapy, the observation group used hormones and TAC combined treatment. Regular follow-up of patients, monitoring 24 h urinary protein, liver and kidney function and other indicators of two groups, the clinical efficacy observed in two groups. Results After treatment, the 24-hour urinary protein and albumin values in the observation group were improved compared with those before treatment, and the difference was statistically significant (P <0.05) compared with the control group. The total effective rate of observation group was 100.00%, higher than 66.67% of control group (P <0.05). Conclusion Higher concentration of TAC can relieve SRNS faster and has curative effect. It is worth further study and application.